Don Kaufman sees two strong bearish opportunities and one "shot" to the upside on Wednesday's Big 3. He sees a likely pullback in the State Street Health Care Sector SPDR ETF (XLV) amidst Moderna's (MRNA) stellar rally. In equities, he sees Arm (ARM) moving "back into a downtrend" while pointing to a tentative upside move in Nike (NKE). Don offers example options trades for his stock picks while Rick Ducat takes a closer look at the key support and resistance levels to watch.