Synopsys (SNPS) opened Wednesday as the biggest laggard in the SPX, down over 30% after it posted weaker-than-expected earnings and guidance. Sam Vadas also mentions commentary from leadership on "expectations of deals that did not materialize" and continuous headwinds in China. The original meme stock, GameStop (GME), shows surprising earnings strength that investors rewarded with a rally. Sam later turns to Novo Nordisk (NVO) after the GLP-1 giant cut 9,000 jobs, along with Klarna's IPO expected later on Wednesday.